Synthesis, Characterization and Antioxidant Activities of Synthetic Chalcones and Flavones

Venkatachalam, H and Nayak, Yogendra and Jayashree, BS (2012) Synthesis, Characterization and Antioxidant Activities of Synthetic Chalcones and Flavones. APCBEE Procedia, 3. pp. 209-213.

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Abstract

In the present study, newer chalcones and flavones were synthesized by Algar-Flynn-Oyamada method, purified and characterized by spectral methods. The pure test compounds were evaluated for in vitro antioxidant activity using four models namely l,l-Diphenyl-2-picrylhydrazyl radical (DPPH>), 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS#), Nitric oxide (NO) and Lipid Peroxidation scavenging methods. This study indicate that, amongst the ten evaluated chalcones and flavones, five test compounds showed activity with IC50 value lesser than that of the standard ascorbic acid at 91.21 uM for 2,2-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging.

Item Type: Article
Uncontrolled Keywords: Chalcones; Flavones; Antioxidantlntroduction.
Subjects: Health Sciences > KMCIC
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 06 Oct 2012 09:15
Last Modified: 06 Oct 2012 09:15
URI: http://eprints.manipal.edu/id/eprint/77351

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