Effect of ethanol extract of Sphaeranthus indicus on cisplatininduced nephrotoxicity in rats

Mathew, Jessy Elizabeth and Joseph, Alex and Keloth Kaitheri, Srinivasan and Dinakaran, Seekarajapuram Vachala and Mantri, Anand and Movaliya, Vinit (2012) Effect of ethanol extract of Sphaeranthus indicus on cisplatininduced nephrotoxicity in rats. Natural Product Research, 26 (10). pp. 1-6. ISSN 1478–6419

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Cisplatin is an anticancer drug extensively used against a variety of cancers. Cisplatin chemotherapy is found to manifest dose-dependent nephrotoxicity. Depletion of the renal antioxidant defence system has been suggested to be the main cause of cisplatin-induced nephrotoxicity. The purpose of this study is to investigate whether the ethanol extract of entire plant of Sphaeranthus indicus could reduce the intensity of toxicity in albino rats. Nephrotoxicity was assessed by determining the serum creatinine and urea levels and renal antioxidant status in rats after cisplatin administration (12 mgkg�1 body weight, i.p.). The ethanol extract of S. indicus (150 and 300mg kg�1 body weight) was administered orally from the sixth day onwards for 10 days after cisplatin administration. The extract significantly reduced the elevated serum creatinine and urea levels. Renal antioxidant defence systems, such as superoxide dismutase, catalase, glutathione peroxidase activities and reduced glutathione level that are depleted by cisplatin therapy were restored to normal by treatment with the extract. Cisplatin-induced lipid peroxidation was also found to be markedly reduced by treatment with the extract. These results suggest that S. indicus has protective effect against cisplatin-induced nephrotoxicity, which may be attributed to its antioxidant potential.

Item Type: Article
Uncontrolled Keywords: Sphaeranthus indicus; cisplatin; nephroprotective; histopathological examination; lipid peroxidation
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 18 Oct 2012 10:55
Last Modified: 18 Oct 2012 10:55
URI: http://eprints.manipal.edu/id/eprint/77466

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