Synthesis and biological Evaluation of 2- Phenyl Chromen -4- ones for their Antioxidant and Antimicrobial Activity

Srinivasan, KK and Goomber, Amit and Kumar, Suthar Sharad and Thomas, Angel Treasa and Joseph, Alex (2010) Synthesis and biological Evaluation of 2- Phenyl Chromen -4- ones for their Antioxidant and Antimicrobial Activity. Pharmacologyonline, 3. pp. 31-37.

[img] PDF
Pharmacology_Online_Paper2010-alex.pdf - Published Version
Restricted to Registered users only

Download (180kB) | Request a copy

Abstract

Claisen-Schmidt condensation reaction of aldehydes and ketones afforded intermediate chalcones, which were cyclized into final products as substituted 2- phenyl chromen-4-ones. The synthesized compounds were characterized by physicochemical and spectral studies. All the synthesized eight compounds were screened for antioxidant activity by DPPH radical scavenging assay method and antibacterial activity against S. aureus, B. subtilis (gram +ve), P. aeruginosa, E. coli, (gram –ve) and antifungal activity against C. albicans and A. niger. All the synthesized compounds have shown moderate antioxidant activity while the compounds AFLV-4, -7, -8 exhibited considerable antimicrobial activity.

Item Type: Article
Uncontrolled Keywords: chromen-4-ones, antioxidant, antimicrobial.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 19 Oct 2012 06:16
Last Modified: 19 Oct 2012 06:16
URI: http://eprints.manipal.edu/id/eprint/77468

Actions (login required)

View Item View Item