Salian, Sujit Raj and Rao, Satish BS and Kalthur, Guruprasad and Kumar, Pratap and Adiga, Satish Kumar (2012) The extent of paternal sperm DNA damage influences early post-natal survival of first generation mouse offspring. European Journal of Obstetrics & Gynecology and Reproductive Biology. pp. 1-4.

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Abstract

Objectives: To study the post-natal characteristics and the survival of offspring derived from DNA damaged sperm. Study design: This experimental prospective study was conducted on Swiss Albino mice (Mus musculus). Sperm DNA damage was induced by different doses of g-irradiation in male mice who were then mated with healthy female mice. The post-natal characteristics including the survival of first generation offspring were studied and then correlated with the amount of paternal sperm DNA damage. Results: A significant reduction of survival in the early post-natal period was observed in the first generation offspring derived from the DNA damaged sperm, and a strong association was observed between the extent of sperm DNA damage and the survival of the offspring. Conclusion: The DNA damage load in sperm at the time of fertilization influences early post-natal survival of the mouse offspring.

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