Effect of ethanol extract of Graptophyllum pictum (L) Griff. on cisplatin induced nephrotoxicity in rats

Srinivasan, Keloth Kaitheri and Mathew, Jessy Elizabeth and Joseph, Kerryn and Dinakaran, Seekarajapuram Vachala (2011) Effect of ethanol extract of Graptophyllum pictum (L) Griff. on cisplatin induced nephrotoxicity in rats. Herba Polonica, 57 (2). pp. 49-62.

[img] PDF
Effect_of_ethanol-herba...pdf - Published Version
Restricted to Registered users only

Download (5MB) | Request a copy

Abstract

The purpose of the present study is to investigate whether the alcoholic extract of Graptophyllum pictum (L.) Griff. could decrease the intensity of nephrotoxicity in albino rats. Cisplatin at a single dose of 12 mg/kg body weight was administered intraperitonially to albino male Wistar rats. Nephrotoxicity was assessed by determining the serum creatinine and urea levels as well as renal antioxidant status in rats after cisplatin administration. Ethanolic extract of G. pictum at 150 and 300 mg/kg body weight was administered orally after cisplatin injection for 15 days. The extracts could significantly reduce the elevated serum creatinine and urea levels. Renal antioxidant defence systems, such as superoxidem dismutase, catalase, glutathione peroxidase activities and reduced glutathione level, depleted by cisplatin therapy were restored to normal by treatment with the extract. Cisplatin induced lipid peroxidation was also found markedly reduced by treatment with the extract. This result indicated that ethanolic extract of G. pictum rendered significant preventive effect against cisplatin induced nephrotoxicity.

Item Type: Article
Uncontrolled Keywords: Antioxidant; Acanthaceae; free radical oxidative stress; cisplatin-induced renal damage; nephrotoxicity; Graptophyllum pictum.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 23 Nov 2012 05:17
Last Modified: 23 Nov 2012 05:17
URI: http://eprints.manipal.edu/id/eprint/77626

Actions (login required)

View Item View Item