Syntheses, characterization and antimicrobial activity of novel 1,3,4 - thiadiazole derivatives

Mathew, Jessy Elizabeth and Vachala, Dinakaran and Srinivasan, KK and Jain, Pankaj C (2009) Syntheses, characterization and antimicrobial activity of novel 1,3,4 - thiadiazole derivatives. Pharmacologyonline, 2. pp. 846-851.

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In the present study, a new series of 2, 5-disubstituted-1, 3, 4-thiadiazole derivatives were synthesized from thiosemicarbazides by condensing with different aromatic acids. The chemical structures of compounds were established on the basis of elemental and spectral data analysis. These compounds were screened for their antimicrobial activity at the level of 40μg/ml against seven organisms. Only the compounds 2-(3',4',5'- trihydroxyphenyl)-5-(4'-methoxyphenylamino)-1,3,4-thidiazole (PA2) and 2-(3'- pyridinyl)-5-(4'-methoxy phenyl amino)-1,3,4-thidiazole (PA3) showed good antibacterial activity against S.sonnei and P.aeruginosa, remaining compounds showed resistance to these organisms. Compounds 2-(3',4',5'-trihydroxyphenyl)-5-(4'-methoxy phenylamino)-1,3,4-thidiazole (PA2), 2-(3'-pyridyl)-5-(4'-methoxyphenylamino)-1, 3, 4-thidiazole (PA3) and 2-(3'-pyridinyl)-5-(4'-bromophenylamino)-1,3,4-thidiazole (BA3) showed better spectrum of antimicrobial activity.

Item Type: Article
Uncontrolled Keywords: thiadiazole, thiosemicarbazides, cyclization, antimicrobial activity.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 23 Nov 2012 09:35
Last Modified: 05 Nov 2016 09:18

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