Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica

Mathew, Jessy Elizabeth and Kaitheri, Srinivasan Keloth and Vachala, Seekarajapuram Dinakaran (2011) Anti-inflammatory, Antipruritic and Mast Cell Stabilizing Activity of Aristolochia Indica. Iranian Journal of Basic Medical Sciences, 14 (5). pp. 422-427.

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Abstract

Objective(s):Aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. In the present study different extracts of roots of A. indica were evaluated for their antiinflammatory, antipruritic and mast cell stabilizing activity. Materials and Methods:Anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and antipruritic activity by examining the incidence of scratching behavior. Mast cell stabilizing activity was performed by compound 48/80 and sheep serum induced mast cell degranulation methods. Results:The ethanol extract (300 mg/kg) and petroleum ether extract (100 mg/kg) were found to inhibit mast cell degranulation significantly equivalent to that of standard drug ketotifen (69%) by compound 48/80 model. In sheep serum model the ethanol extracts (150 and 300 mg/kg) and petroleum ether extract (100 mg/kg) showed good mast cell stabilizing activity (66-67%). Ethanol extract at 150 mg/kg showed 70% reduction of rat paw oedema and also significantly reduced the scratching response. Conclusion:Results suggest A. indica has good mast cell stabilizing, anti-inflammatory and antipruritic activity.

Item Type: Article
Uncontrolled Keywords: Anti-inflammatory, Anti-antipruritic, Aristolochia indica, Mast cell stabilizing activity
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 23 Nov 2012 09:36
Last Modified: 23 Nov 2012 09:36
URI: http://eprints.manipal.edu/id/eprint/77629

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