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Evaluation of direct cost of adverse drug reactions to highly active antiretroviral therapy in Indian human immunodeficiency virus positive patients

Rajesh, Radhakrishnan and Vidyasagar, Sudha and Varma, Muralidhar and Guddattu, Vasudeva Evaluation of direct cost of adverse drug reactions to highly active antiretroviral therapy in Indian human immunodeficiency virus positive patients. Journal of Clinical Research in HIV AIDS and Prevention, 1 (1). pp. 1-11. ISSN 2324-7339

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Abstract

In India, interruptions to highly active antiretroviral therapy (HAART) are due to adverse drug reactions (ADRs) and no reports on the direct cost incurred in the management of ADRs to HAART are available. There is a need to study direct cost incurred with ADRs to HAART to explore the high economic cost burden imposed by ADRs to HAART in HIV/AIDS patients. This study was aimed to evaluate the direct cost incurred in the management of ADRs to HAART in Indian HIV positive patients. This prospective study was conducted at a Medicine department in a South Indian tertiary care teaching hospitals were ADRs reporting system exist. HIV-positive hospitalized in-patients were identified and intensively monitored for ADRs to HAART. The World Health Organization (WHO) probability scale was used for causality assessment of ADRs. Modified Hart wig and Siegel scale was used for severity assessment of ADRs.Pearson chi-square test identified association of mean direct cost between ADRs and without ADRs by investigating total mean direct cost. The overall direct cost per ADRs to HAART was found to be higher in the context of expenditure on health care cost in India.

Item Type: Article
Uncontrolled Keywords: Human immunodeficiency virus; direct cost; hospitalized patients; adverse drug reaction; highly active antiretroviral therapy
Subjects: Departments at MU > Statistics
Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Practice
Depositing User: KMC Manipal
Date Deposited: 07 Dec 2012 06:29
Last Modified: 22 Oct 2013 06:11
URI: http://eprints.manipal.edu/id/eprint/77656

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