An Efficient Synthesis of 1,5-Benzodiazepine Derivatives Catalyzed by Potassium Aluminium Sulfate Dodecahydrate & Evaluation of Their Antioxidant Activity

Bhat, Varadaraj G and Shenoy, Gautham G and Jayashree, BS and Kini, Suwarna G and Joseph, Alex and Jeyeprakash, RS and Vachala, SD and Mathew, Jessy Elizabeth and Udupa, N (2012) An Efficient Synthesis of 1,5-Benzodiazepine Derivatives Catalyzed by Potassium Aluminium Sulfate Dodecahydrate & Evaluation of Their Antioxidant Activity. Indo Global Journal of Pharmaceutical Sciences, 2 (3). pp. 279-285.

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Abstract

1,5- Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which have proven its medicinal identity as anticancer, antioxidant, cardiovascular agents, viral infection, anticonvulsant, analgesic, sedative, antidepressive, and hypnotic agents. Keeping this in mind, the current research work is to synthesize 2,3-Dihydro-1H-1,5- Benzodiazepines by the condensation of various substituted chalcones and o-phenylenediamine in the presence of double salt, potassium aluminium sulfate dodecahydrate. The structure of the synthesized molecules was confirmed on the basis of physical data and extensive spectral studies. All the compounds have been screened for antioxidant activity using DPPH radical scavenging method. All the compounds showed good free radical scavenging activity (IC50 value between 62- 15 mcg/ml) when compared with the standard ascorbic acid. The results indicated that 2,3-Dihydro-1H-1,5-Benzodiazepines could be the potential candidates eliciting antioxidant activity, and further studies can be conducted using molecular modeling tools for designing 1,5-benzodiazepines having better activity

Item Type: Article
Uncontrolled Keywords: 1,5-Benzodiazepines; Double Salt; Potassium Aluminium Sulfate Dodecahydrate; Antioxidant; DPPH
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 10 Dec 2012 04:48
Last Modified: 05 Nov 2016 09:17
URI: http://eprints.manipal.edu/id/eprint/77665

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