Synthesis, Spectral Characterization & Antimicrobial Evaluation of Some Novel Pyrimidine-2,4(1H,3H)-diones

Sharma, OP and Shrivastava, Birendra and Bhat, Varadaraj G and Shenoy, Gautham G and Jayashree, BS and Sreenivasan, KK (2012) Synthesis, Spectral Characterization & Antimicrobial Evaluation of Some Novel Pyrimidine-2,4(1H,3H)-diones. Indo Global Journal of Pharmaceutical Sciences, 2 (1). pp. 70-75.

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In the present work, we had synthesized some novel Pyrimidine-2,4-diones by condensing various substituted amines with 3-substituted -6-chlorouracil. The structure of the synthesized compounds was characterized using physical & spectral data. Novel pyrimidine-2,4-(1H,3H)-diones were then screened for their antimicrobial profile using Kirby Bauer Disc Diffusion(KBDD) method. The anti-bacterial data reveals that compounds OBP-08 and OBP-10 had better activity against tested gram-positive organism whereas OBP-06 found to have better anti-fungal activity than rest of the compounds when tested against Aspergillus niger & Penicillium marneffei. This study lead us to conclude that pyrimidine-2,4(1H,3H)-diones may be the desired scaffold to generate lead anti-infective agents

Item Type: Article
Uncontrolled Keywords: Pyrimidine-2,4-dione; Antimicrobial Activity; Synthesis; Bioactive Agents
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 10 Dec 2012 06:49
Last Modified: 10 Dec 2012 06:49

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