Cyclooxygenase-2)765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma

Chakravarthy, Kalyana (2012) Cyclooxygenase-2)765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma. Journal of Investigative and Clinical Dentistry, 3. pp. 182-188.

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Abstract

Aim: Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. Methods: We designed a case-control study to evaluate the susceptibility of the functional )765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous cell carcinoma (n = 150) patients and healthy controls (n = 150). Results: The genotype frequencies of cyclooxygenase-2 765G>G, 765G>C, and 765C>C were 73.3%, 18.66%, and 8.0% in the cancer patients, and 94.66%, 4% and 1.3% in the controls, respectively. The cyclooxygenase-2 GC and CC genotypes were significantly associated (P = 0.0003 and P = 0.01, respectively) with oral squamous cell carcinoma patients, when compared to the controls. The 765G>C genotypes were statistically significant, with habitual tobacco chewing and alcohol consumption + smoking (P = 0.05). Conclusions: This study highlights the genetic variant that might play a role in mediating susceptibility to oral squamous cell carcinoma in this population

Item Type: Article
Uncontrolled Keywords: cycloxygenase-2, habit, oral squamous cell carcinoma, polymorphism, prostaglandin
Subjects: Dentistry > MCODS Manipal > Preventive and Community Dentistry
Depositing User: KMC Manipal
Date Deposited: 03 Jan 2013 09:42
Last Modified: 26 Dec 2015 10:58
URI: http://eprints.manipal.edu/id/eprint/77831

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