In vitro antifungal effect of mouth rinses containing chlorhexidine and thymol

Shrestha, Ashish and Rimal, Jyotsna and Rao, Ashwini and Sequeira, Simon and Doshi, Dolar and Bhat, Gopal Krishna (2011) In vitro antifungal effect of mouth rinses containing chlorhexidine and thymol. Journal of Dental Sciences , 6 (1). pp. 1-5.

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Abstract

Background/purpose: In this in vitro study, we assessed the antifungal effect of mouth rinses containing chlorhexidine and thymol. Materials and methods: The fungistatic activities of chlorhexidine- and thymol-containing mouth rinses were assessed by means of the minimum inhibitory concentration (MIC) and the fungicidal activity was determined by a time-kill assay. Results: The chlorhexidine-containing mouthwash was able to kill all strains of Candida albicans and Candida tropicalis in shorter times compared to the thymol-containing mouthwash. Hexidine showed an MIC of 1:32 for both Candida species, whereas Listerine respectively showed MICs of 1:8 and 1:16 for C. albicans and C. tropicalis. Conclusions: Antimicrobial agents used in the study had good in vitro activity against the two Candida species. Mouth rinses containing chlorhexidine showed superior antifungal and fungicidal activities compared to the thymol-containing mouth rinse. Both antimicrobial agents may be suggested for use as topical antifungal agents.

Item Type: Article
Uncontrolled Keywords: antifungal; chlorhexidine; mouth rinses; oral candidiasis; thymol
Subjects: Dentistry > MCODS Mangalore > Public Health Dentistry
Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 10 Jan 2013 10:52
Last Modified: 21 Apr 2014 05:21
URI: http://eprints.manipal.edu/id/eprint/77926

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