Synthesis, docking study and anticancer activity of coumarin substituted derivatives of benzothiazole

Kini, Suvarna G and Choudhary, Shivani and Mubeen, Muhammad (2012) Synthesis, docking study and anticancer activity of coumarin substituted derivatives of benzothiazole. Journal of Computational Methods in Molecular Design, 2 (1). pp. 51-60. ISSN 2231- 3176

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Abstract

During the last 2 decades, the study of the biological activities of Coumarin derivatives has been the aim of many researchers. Based on these findings, a series of Coumarin substituted benzothiazoles were synthesized by refluxing Coumarin-4-carboxaldehyde and oaminothiophenol in acetic acid. Compounds were characterized by IR, 1H NMR and mass spectroscopy. All the compounds were tested for their anticancer activity against MCF-7 breast cancer cell line with MTT assay. Most of the compounds showed moderate to good anti-breast cancer activity. Docking studies of the synthesized compounds was done with the help of VLife MDS 3.0 software using GRIP batch docking method to study their observed activity.

Item Type: Article
Uncontrolled Keywords: Anticancer, Synthesis, Docking, Tyrosine kinase, MCF-7 cell line.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 14 Jan 2013 05:25
Last Modified: 14 Jan 2013 05:25
URI: http://eprints.manipal.edu/id/eprint/77976

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