Nonneoplastic granulomatous splenomegaly as the presenting feature of Nodal Hodgkin’s disease

Rao, Anuradha CK and Pruthvi, BC and Rupashree, S and Rao, Lakshmi and Jayaprakash, B and Shanbhogue, Vikram and Rau, NR (2010) Nonneoplastic granulomatous splenomegaly as the presenting feature of Nodal Hodgkin’s disease. Calicut Medical Journal, 8 (1). pp. 1-3.

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Abstract

Non caseating granulomas in association with Hodgkin’s disease have been observed and described previously, though there is a conjecture regarding the significance of such an association. This is a case of a 70 year old female presenting with moderate to high grade, intermittent fever. An examination revealed splenomegaly, with CT scan raising a suspicion of lymphoma. Splenectomy performed, was diagnosed histopathologically as granulomatous splenomegaly, probably Tuberculosis. Antituberculous therapy was started; however, a two month follow –up period showed persistence of fever along with a right supraclavicular node enlargement, prompting a biopsy. The lymph node showed features of Classical Hodgkin’s lymphoma. This brings to attention the fact that, noninfectious granulomas in the spleen, in the absence of clinical or pathological evidence of malignant lymphoma should merit an active follow up and search to detect a remote focus of nodal lymphoma

Item Type: Article
Uncontrolled Keywords: Nonneoplastic, Granuloma, Splenomegaly, Hodgkin’s lymphoma
Subjects: Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 19 Jan 2013 06:45
Last Modified: 19 Jan 2013 06:45
URI: http://eprints.manipal.edu/id/eprint/78025

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