Moorkoth, Sudheer and Srinivasan, KK and Bukka, Divyashree (2013) Evaluation of antimicrobial activity of 4-arylidene-2-phenyl oxazol-5-one derivatives against selected skin microorganisms. Elixir Pharmacy, 54. pp. 12315-12318. ISSN 2220-712X

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Abstract

Five derivatives of oxazolone were synthesized by using Erlenmeyer azlactone synthesis. Antibacterial and antifungal activity of these oxazolones was evaluated on selected skin microorganisms. Preliminary screening was performed to identify growth inhibition, and MIC (Minimum Inhibitory Concentration) was determined for the active compounds. Results obtained were very promising and the most active compound in our screen was the dimethoxy substituted oxazolone, which demonstrated a significant enhancement of antimicrobial activity both against selected bacterial and fungal strains. The MIC value of the highly active compound was found to be 12.5μg/ml.

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