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Role of Moringa oliefera leaf extract in protecting cadmium induced testicular damage in male Wistar Albino rats

*, Vinodini N.A and Chatterjee, Pratik Kumar and *, Rakshatha R and Singh, Renjith R and *, Anwar Amemarsoofi and Kini, Rekha D and Pai, Sheila R (2013) Role of Moringa oliefera leaf extract in protecting cadmium induced testicular damage in male Wistar Albino rats. The Journal of Free Radicals and Antioxidants, 139. pp. 135-140.

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Abstract

Our industrialized society has left a toxic footprint in our environment. We are becoming more & more exposed to the environmental hazardous materials. Cadmium is one of these toxicants affecting various organs including testis & can also induce oxidative stress. At present it’s well established that oxidative stress is one of the most important causes leading to male infertility. Herbal remedies including Moringa leaf extract can be used to combat toxicity of these materials. The present study was conducted to evaluate the role of Moringa olifera leaf extract on serum testosterone, tissue lipid peroxidation & testicular weight in cadmium exposed rats. Male wistar albino rats were divided into four groups with group I being the control. Pretreatment with Moringa leaf extract prior to the administration of cadmium showed a significant increase in the testosterone levels, testicular weight & a decrease in the tissue lipid peroxidation as compared to the cadmium treated group. Therefore, the present study suggests that pre - treatment with Moringa olifera leaf extract alters the testosterone levels, prevents cadmium chloride induced testicular damage & hence can protect us from the toxic effect of this hazardous material. However, further investigations are needed to know the detailed mechanism triggering these protective effects.

Item Type: Article
Uncontrolled Keywords: Cadmium, Moringa oliefera, testosterone, lipid peroxidation
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 07 Feb 2013 10:07
Last Modified: 07 Feb 2013 10:07
URI: http://eprints.manipal.edu/id/eprint/78179

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