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Can Reflex UroVysion fluorescence in situ hybridization predict tumor recurrence during follow-up?

Kurien, Annamma and Thomas, Joseph (2007) Can Reflex UroVysion fluorescence in situ hybridization predict tumor recurrence during follow-up? Indian Journal of Urology, 23 (3). pp. 333-334.

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Abstract

The primary aim of this study was to demonstrate the usefulness of multitarget fluorescence in situ hybridization (FISH UroVysion) testing in the early detection of recurrent urothelial carcinoma (UC). The study population comprised patients with bladder tumor on follow-up, who had negative or atypical urine cytology with no evidence of recurrence by cystoscopy. Some of these patients had positive UroVysion FISH in the urine cell sample. The paper looks at the course of these "anticipatory positive" cases with special reference to the recurrence and the time to tumor recurrence. Fifty-six (26.5%) of the 211 patients with negative cystoscopy and negative or atypical cytology had positive FISH results. This group formed the anticipatory positive subset of patients. Recurrent urothelial carcinoma developed in 35 (62.5%) of these 56 patients. Of these recurrent tumors 22 were high-grade UC and 12 low-grade UC. In about 65% of this anticipatory positive group, recurrent bladder UC bladder developed within 29 months. The recurrence rate was 48% in six months and 54% within 10 months of the positive FISH result. In contrast recurrent UC developed in only eight (5.2%) of the 155 cystoscopically negative, cytologically negative or atypical and FISH negative cases.

Item Type: Article
Subjects: Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Urology
Depositing User: KMC Manipal
Date Deposited: 07 Feb 2013 04:32
Last Modified: 07 Feb 2013 04:32
URI: http://eprints.manipal.edu/id/eprint/78209

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