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Evaluation of Antinociceptive Activity of Vanillin Mediated through Opioid Receptors

*, Rathnakar U P and *, Srikanth D and Menezes, Vishma Hydie and Shenoy, Ashok K and Acharya, Sahana D. and *, Nishchal B S and *, Shivaprakash G and *, Udupa A L (2012) Evaluation of Antinociceptive Activity of Vanillin Mediated through Opioid Receptors. Drug Invention Today, 4 (12). pp. 674-676. ISSN 0975-7619

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Abstract

Vanilla planifolia grown for its attractive aroma has rich medicinal value as evidenced by its antimutagenic, anti-invasive and anti-inflammatory activities. An analgesic activity mediated by opioid receptors has been suggested in earlier studies. Inbred adult wistar rats of either sex weighing 150-200grams were used for the study. Rats were randomly assigned to four groups [Control, morphine 2mg/kg, Vanillin 10mg/kg, Vanillin 100mg/kg] of six animals each. Eddy’s hot plate method was used to evaluate analgesic activity. Naloxone pretreatment was employed to demonstrate any activity mediated through opioid receptors. There was significant increase (P<0.001) in latency period at 10mg/kg and 100 mg/kg doses of vanillin when compared to control. Naloxone pre-treatment significantly reduced the latency period in hot-plate test with both the doses of vanillin. Vanillin at a dose of 10 mg/kg and 100 mg/kg demonstrated a significant increase in latency period, displaying a potential central analgesic activity probably mediated through opioid receptors.

Item Type: Article
Uncontrolled Keywords: Vanillin, Naloxone, Eddy’s hot plate, latency, analgesic
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 07 Feb 2013 10:05
Last Modified: 07 Feb 2013 10:05
URI: http://eprints.manipal.edu/id/eprint/78253

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