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Association between bipolar affective disorder and thyroid dysfunction

*, Vinay Narasimha Krishna and Thunga, Ravish and *, B. UnniKrishnan and Kanchan, Tanuj and *, Mario Joseph Bukelo and Mehta , Rajesh Kumar and *, Anand Venugopal (2013) Association between bipolar affective disorder and thyroid dysfunction. Asian Journal of Psychiatry , 6 (1). pp. 42-45.

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Abstract

Background: Bipolar affective disorder may be associated with alterations in thyroid function. Acomprehensive thyroid assessment is important for assessing clinical and sub-clinical imbalances linkedto a variety of mood disorders like bipolar affective disorder.Aim: To find out the association between bipolar affective disorder and thyroid dysfunction.Materials and method: The present cross-sectional study was conducted at Government District WenlockHospital, Mangalore (GDWH), India. A total of 50 newly diagnosed bipolar affective disorder patients and50 age and sex matched controls without bipolar affective disorder as confirmed by the application ofBipolar Spectrum Diagnostic Scale were included in the study. Thyroid function was assessed among thepatients and control group to study the association between bipolar affective disorder and thyroiddysfunction. Odds ratio was calculated to find out the strength of association between thyroid glanddysfunction and bipolar affective disorder.Results: The mean Bipolar Spectrum Diagnostic Scale score among patients diagnosed with bipolaraffective disorder was 20.84 and that of the control group was 1.98. The proportion of thyroiddysfunction among bipolar affective disorder patients and among control group was 14% and 6%respectively. The odds ratio was calculated to be 2.55. Mean T3 values were higher in the bipolar affectivedisorder patients than the control group and this association was found to be statistically significant(p = 0.031). Mean T4 and TSH values were higher among the bipolar affective disorder patients but didnot show any significant differences when compared with the control group.Conclusion: The present study concludes that a statistically significant association exists betweenelevated T3 hormone and bipolar affective disorder and observes that the patients with bipolar affectivedisorder are 2.55 times more commonly associated with thyroid dysfunction.

Item Type: Article
Uncontrolled Keywords: Bipolar affective disorder;Thyroiddysfunction;Cross-sectionalstudy;Association Bipolar Spectrum Diagnostic Scale
Subjects: Medicine > KMC Mangalore > Psychiatry
Medicine > KMC Mangalore > Radio Diagnosis and Imaging
Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Forensic Medicine
Depositing User: KMCMLR User
Date Deposited: 08 Feb 2013 10:12
Last Modified: 08 Feb 2013 10:12
URI: http://eprints.manipal.edu/id/eprint/78294

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