Pilot study of salivary butyrylcholinesterase, phosphodiesterase, thiols and cerulopalsmin in auditory neuropathy

Prakash, Hari and Prabhu, Krishnananda and Poojari, Kailesh and Prabhu, Bhavya and Malik, Rimshida and Rao, Anjali (2012) Pilot study of salivary butyrylcholinesterase, phosphodiesterase, thiols and cerulopalsmin in auditory neuropathy. Asian Pacific Journal of Tropical Disease, 2. pp. 471-474.

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Abstract

Objective To estimate butyrylcholinesterase (BChE), phosphodiesterase (PDE), thiols and cerulopalsmin by non – invasive means in saliva a of subjects (both cases and controls) and correlated to their hearing sensitivity. Methods Total of 13 subjects participated in this study. Among them 7 were having auditory neuropathy and 6 were healthy controls. Unstimulated saliva (10 ml) was collected from each participant. Ceruloplasmin, thiols, phosphodiesterase and pseudocholinesterase were estimated by colorimetric method in the salivary samples. Results Salivary BChE and PDE levels were marginally elevated and protein thiols were marginally decreased in cases as compared to that of controls. Salivary ceruloplasmin was significantly decreased (p = 0.022) in cases as compared to that of controls. Conclusions Saliva can be used as a potential noninvasive tool for evaluation of disorders.

Item Type: Article
Uncontrolled Keywords: Saliva;Auditory neuropathy;Phosphodiesterase; Butyrylcholinesterase;Ceruloplasmin;Protein thiols
Subjects: Allied Health > MCOAHS Manipal > Speech and Hearing
Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > ENT
Depositing User: KMC Manipal
Date Deposited: 12 Feb 2013 10:21
Last Modified: 12 Feb 2013 10:21
URI: http://eprints.manipal.edu/id/eprint/78376

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