Synthesis, Characterization and Antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives

Chandrakantha , B and Isloor, Arun M and Shetty, Prakash and Isloor, Shrikrishna and Malladi, Shridhar and Fun, Hoong-Kun (2012) Synthesis, Characterization and Antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives. Medicinal Chemistry Research , 21 (9). pp. 2702-2708. ISSN 1554-8120

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Official URL: http://link.springer.com/article/10.1007%2Fs00044-...

Abstract

In the present study, a novel series of Pyrazole derivatives (3a–m) were synthesized by condensing ethyl- 3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studies as well as by C, H, and N analyses. All the newly synthesized compounds were screened for their antibacterial properties against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Among the screened samples, 3c, 3f, 3k, and 3l have showed excellent antibacterial activity against all the tested bacterial strains as compared to the standard drug Ceftriaxone. Few of the compounds were found to be biologically potent. Molecular structure of compound 3i was confirmed by single crystal X-ray analysis.

Item Type: Article
Uncontrolled Keywords: Pyrazole � Antibacterial study � MIC
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 16 Feb 2013 04:13
Last Modified: 16 Feb 2013 04:13
URI: http://eprints.manipal.edu/id/eprint/78440

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