L-asparaginase from marine derived fungal endophytes of seaweeds

Murali, TS (2011) L-asparaginase from marine derived fungal endophytes of seaweeds. Mycosphere. pp. 147-155.

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Abstract

Symptomless endophytic fungi isolated from seven green algae, six brown algae and six red algae occurring along the southern coast of Tamilnadu, southern India were screened for the production of L-asparaginase enzyme. Of the 82 endophyte isolates, 64 were positive for the enzyme. A Fusarium sp. isolated from the thallus of Sargassum wightii and a sterile mycelial form isolated from the thallus of Chaetomorpha sp. showed maximum activity of the enzyme. The mycelial growth of Fusarium sp. was positively correlated with enzyme production. In a time course study, maximum enzyme activity was observed on the 5th day of growth of this fungus. The optimum pH for enzyme activity was pH 6.2. High concentration of glucose in the medium as C source inhibited enzyme production by the fungus. Endophytes of tropical seaweeds appear to be a good source of this therapeutic enzyme

Item Type: Article
Uncontrolled Keywords: Endophytes – tropical seaweeds – anti neoplastic – acute lymphoblastic leukaemia
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 15 Feb 2013 11:04
Last Modified: 15 Feb 2013 11:04
URI: http://eprints.manipal.edu/id/eprint/78455

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