Rai, Padmalatha S (2012) Hepatoprotective Properties of Alstonia Scholarsis Againts Carbon Tetra Chloride Induced Hepatic Damage In Rats. International Journal of Institutional Pharmacy and Life Sciences, 2 (4). pp. 22-30. ISSN 2249-6807

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Abstract

Alstonia scholaris Linn (Apocynaceae) known as Saptaparna, is a medium sized tree known for its pharmacological activities like antimicrobial, antimalarial, antidote for snake bite and anticholeric properties etc. This evergreen tree is a native to the Indian sub-continent and South East Asian countries. In the present study carbon tetrachloride (CCl4) induced liver damage model has been employed as a tool to assess the hepatoprotecitive activity of ethyl acetate, hexane and methanol extracts of Alstonia scholaris. Significant increase in the total serum protein is observed in the blood serum of animals treated with methanol, hexane and ethyl acetate extract of leaf of Alstonia scholaris indicating the protection of normal regulatory homeostatic function of liver. Thus the current study reveals that plant extracts from the plant Alstonia scholaris have significant hepatoprotective property.

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