Rai, Padmalatha S (2012) Evaluation of Wound Healing Activity of Vitis Vinifera Stem Bark Extracts in Rats. International Journal of Institutional Pharmacy and Life Sciences, 2 (3). pp. 302-310. ISSN 2249-6807

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Abstract

The present study was aimed for wound healing potential of chloroform and ethanolic extract of Vitis vinifera (stem bark) using three types of wound models in rats as incision wound, excision wound and dead space wound. The results were obtained in terms of wound contraction, epithelialization time, tensile strength, hydroxyproline content and granuloma weight. Enhanced wound contraction and decreased epithelialization time were observed in extract-treated animals in excision wound model. The tensile strength of the incision wound was significantly increased in comparison to control group. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in treated animals compared with control (p<0.01).

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