Granulomatous slack skin

Pai, Kanthilatha and Pai, Sathish B and Rao, Ravikala and Devadiga, Rama and Shenoi, Shrutakirthi D (2000) Granulomatous slack skin. International Journal of Dermatology, 39. pp. 363-382.

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A 32-year-Old man presented with multiple subcutaneous swellings of 6 years' duration. A biopsy performed 6 years earlier, when the patient presented with papules and plaques, was I reported as tuberculoid Hansen's disease. The patient received dapsone, but showed no I improvement. The disease was progressive. The patient currently has bilateral parotid 1 enlargement (Fig. 1), enlarged submandibular, SUbmental, and axillary lymph nodes, multiple J subcutaneous swellings over the axillae and arms of cricket ball size, loose skin. folds in the axillae (Fig. 2) and groin, and dry, scaly, and ichthyotic skin all over the body. Clinical differential diagnoses of mycosis fungoides and cutis laxa were made. The patient was discharged on request and then was lost to follow-up. Biopsies taken from the axillary fold, right arm, and face revealed dense infiltration of the dermis and subcutis by aggregates of small lymphocytes, some exhibiting nuclear convolutions along with one or two Langhans-type giant cells (Fig. 3). A few giant cells showed evidence of Iymphophagocytosis. Blood vessel walls were infiltrated by lymphocytes. Epidermotrophism was seen in biopsies from the arm and face (Fig. 4). There was partial loss of elastic fibers in the dermis. A histopathologic diagnosis of granulomatous slack skin (GSS) was made.

Item Type: Article
Subjects: Medicine > KMC Manipal > Dermatology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 22 Feb 2013 11:28
Last Modified: 22 Feb 2013 11:28

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