Epigenetics Mechanisms and Degenerative Diseases

Bhat, Smitha and Satyamoorthy, K (2012) Epigenetics Mechanisms and Degenerative Diseases. Open Journal of Genetics, 2. pp. 173-183.

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Abstract

Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms in- clude histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environ- ment interactions. Such epigenetic modifications des- pite being heritable and stably maintained are also potentially reversible and there is scope for the de-velopment of epigenetic therapies for this disease

Item Type: Article
Uncontrolled Keywords: Epigenetics; DNA Methylation; Histone Modifications; DNA Methylation; Rheumatoid Arthritis
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 27 Feb 2013 04:15
Last Modified: 22 Oct 2016 15:23
URI: http://eprints.manipal.edu/id/eprint/78742

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