Antioxidant and Radiation Antagonistic Effect of Saraca indica

Rao, Satish BS and Rao, Nageshwar B and Archana, PR and Gayathri, P (2010) Antioxidant and Radiation Antagonistic Effect of Saraca indica. Journal ojEnvironmental Pathology, Toxicology, and Oncology, 29 (1). pp. 69-79. ISSN 0731-8898

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Abstract

The present study was undertaken to investigate the radiation mitigating effect of hydro-alcoholic extract of Saraca indica (SIE) against mice exposed to whole body gamma radiation. Free radical scavenging ability by SIE was demonstrated using hydroxyl, superoxide anion, ABTS·+ and DPPH radicals generated in vitro. A significant increase in the animal survival (dose reduction factor = 1.39), inhibition in the decline of hematological parameters as well as increased number of spleen colony-forming units was observed when SIE was administered prior to radiation. SIE pretreatment increased the levels of glutathione, glutathione S- transferase, catalase and lowered lipid peroxidation. Our findings for the first time demonstrate the protective potential of SIE against radiation induced syndromes with an optimal dose of 400 mg/kg hwt. The radiation mitigating effect may be attributed to the mechanisms such as free radical scavenging, elevation in antioxidant status, and reduction in lipid peroxidation.

Item Type: Article
Uncontrolled Keywords: antioxidants, Gamma radiation, micronuclei, radioprotection, Saraca indica
Subjects: Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 27 Feb 2013 10:59
Last Modified: 27 Feb 2013 10:59
URI: http://eprints.manipal.edu/id/eprint/78778

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