Excellent tolerance to cilnidipine in hypertensives with amlodipine - induced Edema

Shetty, Ranjan and Vivek, G and Naha, Kushal and Tumkur, Anil and Raj, Abhinav and Bairy, KL (2013) Excellent tolerance to cilnidipine in hypertensives with amlodipine - induced Edema. North American Journal of Medical Sciences |, 5 (1). pp. 47-50.

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Background: Ankle edema is a common adverse effect of amlodipine, an L-type calcium channel blocker (CCB). Cilnidipine is a newer L/N-type CCB, approved for treatment of essential hypertension. Aim: This study was designed to determine whether cilnidipine can produce resolution of amlodipine-induced edema while maintaining adequate control of hypertension. Materials and Methods: A prospective study was performed on 27 patients with essential hypertension with amlodipine-induced edema. Concomitant nephropathy, cardiac failure, hepatic cirrhosis, or other causes of edema, and secondary hypertension were excluded by appropriate tests. Amlodipine therapy was substituted in all the cases with an efficacy-equivalent dose of cilnidipine. Clinical assessment of ankle edema and measurement of bilateral ankle circumference, body weight, blood pressure, and pulse rate were performed at onset of the study and after 4 weeks of cilnidipine therapy. Results: At completion of the study, edema had resolved in all the patients. There was a significant decrease in bilateral ankle circumference and body weight ( P < 0.001). There was no significant change in mean arterial blood pressure and pulse rate. Conclusions: Therapy with cilnidipine resulted in complete resolution of amlodipine-induced edema in all the cases without significant worsening of hypertension or tachycardia. Cilnidipine is an acceptable alternative antihypertensive for patients with amlodipine-induced edema.

Item Type: Article
Uncontrolled Keywords: Ankle edema, Calcium channel blocker, Cilnidipine, Hypertension, L/N-type calcium channel
Subjects: Medicine > KMC Manipal > Cardiology
Medicine > KMC Manipal > Medicine
Pharmacy > MCOPS Manipal > Pharmacy Management
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 05 Mar 2013 09:48
Last Modified: 05 Mar 2013 09:48
URI: http://eprints.manipal.edu/id/eprint/78844

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