Antiamnesic and Neuroprotective Effects of Low Dose of Ramipril and Losartan in Scopolamine-Induced Amnesia Model of Dementia

Deb, Debasree and Nayak, Veena and Bairy, KL and Rao, Mohandas KG and Shetty, Jeevan and Hegde, Mangala V and Koshy, Salini S (2013) Antiamnesic and Neuroprotective Effects of Low Dose of Ramipril and Losartan in Scopolamine-Induced Amnesia Model of Dementia. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 4 (1). pp. 1174-1182. ISSN 0975-8585

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Abstract

To investigate the potential role of ramipril and losartan in preventing scopolamine-induced memory impairment in rats. Memory impairment was induced in male Wistar rats by administration of scopolamine (1 mg/kg intraperitoneally). Rats received oral doses of ramipril (0.225 mg/kg) and losartan (2.25 mg/kg) for a period of four weeks. Passive avoidance paradigm was used to assess learning and memory. Biochemical estimations of malondialdehyde, glutathione transferase, protein thiols, and histological analysis of hippocampal morphology were performed to estimate the degree of oxidative stress and neuronal degeneration. Pre-treatment with ramipril and losartan reversed scopolamine-induced memory impairment, oxidative stress and hippocampal degeneration which were evident by the findings from behavioral, biochemical and histological studies

Item Type: Article
Uncontrolled Keywords: Memory; Hippocampus; Oxidative stress; Scopolamine; Ramipril; Losartan
Subjects: Medicine > KMC Manipal > Anatomy
Medicine > KMC Manipal > Biochemistry
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 05 Mar 2013 10:13
Last Modified: 05 Mar 2013 10:13
URI: http://eprints.manipal.edu/id/eprint/78856

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