Pai, Kanthilatha and Baliga, Poornima (2013) E-Cadherin Expression: A Diagnostic Utility for Differentiating Breast Carcinomas with Ductal and Lobular Morphologies. Journal of Clinical and Diagnostic Research. pp. 1-5.
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Abstract
Objectives: The objective of this study was to evaluate the diagnostic utility of the E-Cadherin (EC) expression in differentiating between an infiltrating ductal carcinoma (IDC) and an infiltrating lobular carcinoma (ILC), the two most common forms of invasive breast carcinomas. Methods: The authors evaluated the E-Cadherin expression by doing immunohistochemistical studies of all the cases of invasive lobular carcinomas (ILC) which were diagnosed in the pathology laboratory during a 3 year period and they compared the expression of E-Cadherin in an equal number of invasive ductal carcinomas (IDC) of the breast. Results: A moderate to strong inter-membranous E-Cadherin expression on immunohistochemistry was seen in all the cases of IDC, while only 1 case of ILC showed a moderate E-Cadherin expression. Hence, the E-cadherin expression can be reliably used as a marker to differentiate IDC and ILC. However, an aberrant cytoplasmic expression of E-Cadherin may be seen in some cases of ILC, which should be interpreted with caution.
Item Type: | Article |
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Uncontrolled Keywords: | E-Cadherin, Breast carcinoma |
Subjects: | Medicine > KMC Manipal > Pathology |
Depositing User: | KMC Manipal |
Date Deposited: | 23 Mar 2013 06:23 |
Last Modified: | 23 Mar 2013 06:23 |
URI: | http://eprints.manipal.edu/id/eprint/79245 |
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