Transient abnormal myelopoiesis in a neonate

Mallya, Ketan P and Nayak, Deepak M and Belurkar, Sushma V and Manohar, Chethan (2013) Transient abnormal myelopoiesis in a neonate. Journal of Evolution of Medical and Dental Sciences, 2 (3). pp. 184-188.

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Transient abnormal myelopoiesis (TAM) is a unique disorder of newborns associated intimately with Down’s syndrome, presenting with clinical and morphological features indistinguishable from acute myeloid leukaemia (AML). We report a case in a neonate, presenting with severe perinatal asphyxia and cyanosis; complicated by metabolic acidosis. The hemogram revealed leucocytosis and thrombocytopenia. The peripheral smear showed marked left shift and 55% circulating myeloblasts. Additional findings included a hepatomegaly and mild dysmorphic features. The child eventually succumbed to pulmonary hemorrhage on day one itself. TAM has to be differentiated from congenital leukemia which portends a poor prognosis.

Item Type: Article
Uncontrolled Keywords: Transient abnormal myelopoiesis, Down’s syndrome, neonate
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 28 Mar 2013 04:25
Last Modified: 28 Mar 2013 04:25

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