Potential cytotoxic and apoptosis inducing agents: synthesis and evaluation of methoxy-substituted chalcones against human lung and cervical cancers

Aranjani, Jesil Mathew (2013) Potential cytotoxic and apoptosis inducing agents: synthesis and evaluation of methoxy-substituted chalcones against human lung and cervical cancers. Medicinal Chemistry Research.

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Abstract

The role of methoxy group substitution in various positions in both the rings of chalcones on cytotoxicity profile was studied using various synthesized chalcones. The fluorine containing acetophenones when reacted with various methoxy-substituted benzaldehydes in the presence of 10 % sodium hydroxide solution gave the functionalized chalcones. All the synthesized chalcones were confirmed by spectral techniques like FTIR, 1HNMR, 13C NMR, and HRMS studies. All the synthesized compounds were screened for their cytotoxicity against various cell lines. The promising compounds were analyzed for cell cycle analysis.

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