Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study

Soumyanarayanan, Uttara and Bhat, Varadaraj G and Kar, Sidhartha S and Mathew, Jesil A (2012) Monastrol mimic Biginelli dihydropyrimidinone derivatives: synthesis, cytotoxicity screening against HepG2 and HeLa cell lines and molecular modeling study. Organic and Medicinal Chemistry Letters, 2 (23). pp. 1-11.

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Abstract

Biginelli dihydropyrimidinone derivatives as structural analogs of monastrol, a known human kinesin Eg5 inhibitor, were synthesized. IC50 values of the synthesized compounds against the proliferation of human hepatocellular carcinoma and human epithelial carcinoma cell lines were determined through MTT assay. Molecular docking study gave a clear insight into the structural activity relationship of the compounds in comparison with monastrol.

Item Type: Article
Uncontrolled Keywords: Privileged structures; Amide coupling; Mitotic kinesin; Biginelli reaction.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 28 Mar 2013 11:08
Last Modified: 28 Mar 2013 11:08
URI: http://eprints.manipal.edu/id/eprint/79337

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