Nagarethinam, Sivagurunathan and Naik, Anantha Nagappa and Udupa, N and Rao, Venkata J and Vanathi, Meenashi B (2012) Microbial L-Asparaginase and its future prospects. Asian Journal of Medical Research, 1 (4). pp. 159-168. ISSN 2277-7253

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Abstract

L-asparaginase hydrolyses the free L-asparagine and depletes it in blood and selectively drives the leukemic cells to death as these cells cannot synthesize the amino acid on its own. It is used as a first line of therapy for the induction of remission in Acute Lymphoblastic Leukemia. Even though the enzyme selectively targets the cancerous cells its usage in the past is greatly affected due to two main reasons viz., immunogenic complications and glutaminase acitivity. Many prokaryotes and eukaryotes were found to produce the L-asparaginase with or without clinical application. Research oriented towards exploration of novel enzyme with clinical significance and without any immunogenic complication has to be accelerated. Challenges in the drug development to deliverable have to be confronted with available advances in the field of biotechnology. This review describes the key issues related to the use of L- asparaginase in therapy and discusses on the development of novel microbial enzyme by bioprocess technology.

Item Type:	Article
Uncontrolled Keywords:	L-asparaginase; Acute Lymphoblastic Leukemia; immunogenic.
Subjects:	Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User:	KMC Manipal
Date Deposited:	28 Mar 2013 11:17
Last Modified:	28 Mar 2013 11:17
URI:	http://eprints.manipal.edu/id/eprint/79343

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