Antiovulatory and Abortifacient Effects of Areca Catechu (betel nut) in Female Rats

Shrestha, Jyoti and Shanbhag, Tara and Shenoy, Smita and Amuthan, Arul and Prabhu, Krishnananda and Sharma, Stuti and Banerjee, Samik and Kafle, Sajala (2010) Antiovulatory and Abortifacient Effects of Areca Catechu (betel nut) in Female Rats. Indian J Pharmacol, 42 (5). pp. 306-311. ISSN 0253-7613

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Objectives: To study the antiovulatory and abortifacient effects of ethanolic extract of Areca catechu in female rats. Materials and Methods: For antiovulatory effect, ethanolic extract of A. catechu at 100 and 300 mg/kg doses was administered orally for 15 days. Vaginal smears were examined daily microscopically for estrus cycle. Rats were sacrificed on 16th day. Ovarian weight, cholesterol estimation, and histopathological studies were done. Abortifacient activity was studied in rats at 100 and 300 mg/kg doses administered orally from 6th to 15th day of pregnancy. Rats were laparotomised on 19th day. The number of implantation sites and live fetuses were observed in both horns of the uterus. Results: The extract of A. catechu showed a significant decrease in the duration of estrus at 100 mg/kg (P = 0.015) and 300 mg/kg doses (P = 0.002) as compared with control. Metestrus phase was also significantly reduced at 100 mg/kg (P = 0.024) and 300 mg/kg doses (P = 0.002). There was a significant increase in proestrus (P < 0.001) phase. However, diestrus phase was unchanged. Histopathological study of the ovaries showed mainly primordial, primary, and secondary follicles in the test groups as compared to control. There was also a significant (P = 0.002) decrease in ovarian weight and a significant (P = 0.021) increase in ovarian cholesterol level at 100 mg/kg dose. In the study to evaluate abortifacient effect, the mean percentage of abortion with 100 and 300 mg/kg doses were 75.5% and 72.22%, respectively, which was significantly (P = 0.008 and P = 0.006, respectively) increased when compared with control. Conclusion: The ethanolic extract of A. catechu at doses of 100 and 300 mg/kg has antiovulatory and abortifacient effects.

Item Type: Article
Uncontrolled Keywords: Abortifacient, Areca catechu, antiovulatory, implantation sites, ovarian cholesterol
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 06 Apr 2013 10:12
Last Modified: 06 Apr 2013 10:12

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