HIV Vaccines:Present Scenario and Future Prospects

Jesil, Aranjani Mathew and Atulya, M and Palanimuthu, Vasanth Raj and Rao, Venkata J (2011) HIV Vaccines:Present Scenario and Future Prospects. Pharmacologyonline, 2. pp. 90-103. ISSN 1827-8620

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AIDS, first described in early1980s, has reached the far corners of the globe and is the main cause of death throughout the world. Potential adverse effects of the present anti-HIV drugs, multidrug regimens leading to drug resistance and conferring mutations in the virus leading to more virulent forms have provoked the urgency for vaccine development. However, the development of an HIV vaccine faces formidable scientific challenges related to the high genetic variability in the virus, the lack of immune correlates of protection, lack of animal models and logistical problems associated with the conduct of multiple clinical trials. Yet, live vectored recombinant vaccines, replication incompetent viral vectors, subunit vaccines and DNA vaccines have paved the way for the development of a variety of novel and specific vaccine approaches. Researchers are currently exploring the uncharted immunologic terrain which could also prove invaluable. Although they have turned the virus inside-out and carefully detailed how it destroys the immune system, it is yet to unravel which immune responses can fend off an infection indicating, AIDS vaccine research for more than a decade is "flying without a compass."

Item Type: Article
Uncontrolled Keywords: (AIDS) Acquired Immunodeficiency syndrome, (CTLs) Cytotoxic T-lymphocytes, (HIV) Human Immunodeficiency Virus, Vaccines
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Depositing User: KMC Manipal
Date Deposited: 19 Apr 2013 04:25
Last Modified: 19 Apr 2013 04:25

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