β-Catenin Expression in Benign and Malignant Salivary Gland Tumors

Chandrashekar, Chetana and Angadi, Punnya V and Krishnapillai, Rekha (2011) β-Catenin Expression in Benign and Malignant Salivary Gland Tumors. International Journal of Surgical Pathology, 19 (4). pp. 433-440.

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Abstract

Objective. To assess the expression of b-catenin in benign and malignant salivary gland tumors and to investigate the possible role of b-catenin in the behavior of salivary gland tumors. Study design. Paraffin embedded tissues from 45 salivary gland tumors were studied immunohistochemically for expression of b-catenin. Result. Reduced/aberrant b-catenin expression was seen in benign and malignant salivary gland tumors. Cytoplasmic localization and reduced membranous expression were comparatively observed more in malignant salivary gland tumors. Additionally, in pleomorphic adenomas (PAs), b-catenin exhibited intense staining in cells arranged in the form of ducts/tubules, whereas cells in clusters and sheets showed weaker immunoreactivity. Conclusion. Reduced and cytoplasmic localization of b-catenin could indicate lack of differentiation, invasive potential, and aggressive behavior in malignant salivary gland tumors. Furthermore, change in expression based on the arrangement of tumor cells may suggest that b-catenin may have a role in morphological variations seen in PAs.

Item Type: Article
Uncontrolled Keywords: b-catenin, salivary gland tumors, pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, adenocarcinoma
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Manipal
Date Deposited: 26 Apr 2013 06:20
Last Modified: 26 Apr 2013 06:20
URI: http://eprints.manipal.edu/id/eprint/79879

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