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First documented cure of a suggestive exogenous reinfection in polymyositis with same but multidrug resistant M. tuberculosis

Mukhopadhyay, Chiranjoy and Garg, Ankita and Ayyagari, Archana (2004) First documented cure of a suggestive exogenous reinfection in polymyositis with same but multidrug resistant M. tuberculosis. BMC Infectious Diseases, 63 (4). pp. 1-5.

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Abstract

Background: MDR Mycobacterium tuberculosis is the major cause of treatment failure in tuberculosis patients, especially in immunosuppressed. We described a young polymyositis patient on immunosuppressive therapy who was started with antituberculosis therapy as a susceptible strain of M. tuberculosis was isolated from a single cutaneous abscess in his neck and from regional lymph nodes. Case presentation: He had non-reactive miliary tuberculosis and multiple cutaneous abscesses 6 months later with the same strain, which was resistant this time to 9 antituberculosis drugs. We described clinical presentation, radiological and laboratory work-up, treatment and follow-up as the patient was cured after 1.5 years with 6 antituberculosis drugs. Conclusion: To our knowledge, this is the first reported case where an immunosuppressed patient with suggestive exogenous reinfection within 6 months with the same but MDR strain of M. tuberculosis was cured. Intense management and regular follow up were important since the patient was a potent source of MDR M. tuberculosis infection and there was limited choice for therapy

Item Type: Article
Subjects: Medicine > MMMC Maleka
Depositing User: KMC Manipal
Date Deposited: 25 Jul 2011 05:20
Last Modified: 25 Jul 2011 05:20
URI: http://eprints.manipal.edu/id/eprint/916

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