Evaluation of Antimicrobial activity of 3-(4-1H- indol-3-yl)-2,3- dihydro-1H-benzo[b][1,5]diazepin-2-yl)-2H-chromen-2-one

Singla, Rajeev K and Bhat, Varadaraj G and Jagani, Hitesh (2011) Evaluation of Antimicrobial activity of 3-(4-1H- indol-3-yl)-2,3- dihydro-1H-benzo[b][1,5]diazepin-2-yl)-2H-chromen-2-one. Indo Global Journal of Pharmaceutical Sciences, 1 (2). pp. 127-133. ISSN 2249-1023

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Abstract

1,5- Benzodiazepines and its derivatives constitute an important class of heterocyclic compounds which possess wide range of therapeutic and pharmacological properties as anticonvulsant, analgesic, sedative, antidepressive, and hypnotic agents. In the last decade, the area of biological interest of 1,5-Benzodiazepines has been extended to several diseases such as cancer, viral infection and cardiovascular disorders. With this background, we had synthesized RVB-01 (3- (4-1H-Indol-3-yl)-2,3-dihydro-1H-benzo[b][1,5]diazepin-2-yl)-2H-Chromen-2-one) . Structure of this compound have been elucidated by using physical and extensive spectral data. The antimicrobial activity of RVB-01 against B subtilis , P aeruginosa, E coli, M luteus, S aureus was determined by agar diffusion method at 10, 50, 500 and 1000 mcg/ml using ciprofloxacin as a reference. MIC value of RVB-01 against B subtilis was determined by tube dilution method. RVB-01 showed remarkable activity against all microorganisms except E coli and having an MIC value of 250-300 mcg/ml against B subtilis. The results indicated that 2,3-Dihydro-1H-1,5-Benzodiazepines could be the potential candidate eliciting antibacterial activity, and further studies can be conducted using molecular modeling tools for designing 1,5-benzodiazepines having better activity.

Item Type: Article
Uncontrolled Keywords: 1,5- Benzodiazepine; Antimicrobials; Kirby bauer disc diffusion method.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 11 May 2013 04:14
Last Modified: 11 May 2013 04:14
URI: http://eprints.manipal.edu/id/eprint/95011

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