Investigation of Anthramycin Analogs Induced Cell Death in MCF-7 Breast Cancer Cells

Singla, Rajeev K and Paul, Piya and Nayak, Pawan G and Bhat, Varadaraj G (2012) Investigation of Anthramycin Analogs Induced Cell Death in MCF-7 Breast Cancer Cells. Indo Global Journal of Pharmaceutical Sciences, 2 (4). pp. 383-389. ISSN 2249-1023

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Abstract

1,5-Benzodiazepines were synthesized using chalcone & o-phenylene diamine. Their structures were characterized using physical & spectral data. These molecules are analogous to anthracin, henceforth evaluated for their anti-breast cancer activity, using in vitro model MTT assay against MCF-7 cell line. Results revealed that these molecules are having potential growth inhibitory effect on the MCF-7 cell line, and certainly better than that of standard cisplatin. Docking studies revealed that these 1,5-benzodiazepine molecules may be working by inhibiting tyrosine kinase receptor, ErbB4 of human breast adenocarcinoma cell line(MCF-7/Michigan Cancer Foundation-7).

Item Type: Article
Uncontrolled Keywords: 1,5-Benzodiazepines;Potassium Aluminium Sulfate Dodecahydrate;MCF-7 cell.
Subjects: Departments at MU > Manipal Centre for Virus Research
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 11 May 2013 04:20
Last Modified: 11 May 2013 04:20
URI: http://eprints.manipal.edu/id/eprint/95014

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