Synthesis and Antimicrobial Activity of Some New [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole Derivatives

Mudgal, Mukesh M and Singla, Rajeev K and Bhat, Varadaraj G and Shenoy, Gautham G (2009) Synthesis and Antimicrobial Activity of Some New [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole Derivatives. Pharmacologyonline, 2. pp. 188-193.

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Recent observations of literature suggests that molecular manipulation, combination of two or more active moieties into one molecule and synthesis of totally newer moieties have been the method of research. In view of this we have undertaken synthesis of various 6-(pyrazin-2-yl)-3-substituted [1,2,4]triazolo[3,4- b][1,3,4]thiadiazole derivatives and their antibacterial and antifungal activity. The Structures of the synthesized compounds were established with spectral characterizations using UV, IR, 1H-NMR and mass spectra. The Synthesized molecules were tested against bacterial strains (Micrococcus luteus, Bacillus subtilis, Bacillus cereus, Enterobacter aerogenes, E. Coli, Klebsiella pneumonia, Proteus microbilis, Pseudomonas aeruginosa and Staphylococcus aureus, Salmonella typhii, Streptococcus pneumoniae), fungal strains (Candida albicans, Cryptococcus albidus, Trychophyton rubrum, Apergillus niger, A. flavus, A. spinulosus, A. terrcues and A. nidulans) by agar diffusion method. The results of preliminary screening showed that all synthesized 6-(pyrazin-2-yl)-3-substituted [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives has good antibacterial activity against all strains but only few of them showing good activity against Streptococcus pneumoniae . Similarly some of these molecules showed good antifungal activity against all strains except against trychophyton species.

Item Type: Article
Uncontrolled Keywords: Triazole; Thiadiazole; Antibacterial; Antifungal.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 13 May 2013 04:07
Last Modified: 13 May 2013 04:07

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