Synthesis and Antimicrobial Studies Of Some Novel Benzimidazole Derivatives

Reddy, Vijaya B and Singla, Rajeev K and Bhat, Varadaraj G and Shenoy, Gautham G (2009) Synthesis and Antimicrobial Studies Of Some Novel Benzimidazole Derivatives. Asian Journal of Research in Chemistry, 2 (2). pp. 162-167. ISSN 0974-4169

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Abstract

A series of 2-substituted phenoxymethyl benzimidazoles and 1-alkyl-2-substituted phenoxymethyl benzimidazoles (R1X1-4- R8X1-4) were prepared. The structures of the benzimidazole derivatives were confirmed on the basis of spectral data. The compounds were screened for their in vitro antibacterial, antifungal, antituberculars activity using bacterial strains (E. Coli, Pseudomonas aeruginosa and Coagulase positive Staphylococcus aureus {COPS}), fungal strains (Candida albicans and Aspergillus niger) and Mycobacterium tuberculosis H37RV strain. The results of preliminary screening showed that all synthesized 2-(substituted phenoxymethyl) 1-H benzimidazoles and 1- alkyl-2-(substituted phenoxymethyl) benzimidazoles has potential antifungal activity against Candida Albicans, but only few compounds showing activity against Aspergillus niger. Similarly all molecules showed good antibacterial activity against E.coli and Pseudomonas aeruginosa, but very few were resistance to Staphylococcus aureus. And all the synthesized compounds showed good activity against Mycobacterium tuberculosis even at 1 mcg/ml concentration.

Item Type: Article
Uncontrolled Keywords: Benzimidazole; Antibacterial; Antifungal; Antitubercular; Phenoxymethyl.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 13 May 2013 04:11
Last Modified: 13 May 2013 04:11
URI: http://eprints.manipal.edu/id/eprint/95023

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