Synthesis, characterization and antimicrobial activity of some novel 2,3-disubstituted thiazolidin-4-one derivatives

Chandrashekhar, Kumar B and Reddy, Venugopala KR and Fasiulla, . and Shridhara, A M (2013) Synthesis, characterization and antimicrobial activity of some novel 2,3-disubstituted thiazolidin-4-one derivatives. Journal of Chemical and Pharmaceutical Research, 5 (6). pp. 1-6. ISSN 0975-7384

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Abstract

A series of new 3-(4-(p-toluidino)thiazol-2-yl)-2-phenylthiazolidin-4-one derivatives (5a-g) were synthesized from novel schiff base of 2-((4-(p-toluidino)thiazol-2-ylimino)methyl)phenol (4a-g) with thioglycolic acid in presence of anhydrous zinc chloride. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1H NMR, mass spectral data and elemental analysis. Newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of gram +ve and gram -ve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa and fungi strain Candida albicans & Aspergillus nigar at 40 μg/mL. The chloro and bromo substituted 2,3-substituted thiazolidin-4-one derivatives are showing activity as compare to the other functional groups.

Item Type: Article
Uncontrolled Keywords: 2,3-substituted-Thiazolidine-4-one, Schiff base, Thiazole, Elemental analysis, Antimicrobial evaluation.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 24 Sep 2013 04:25
Last Modified: 24 Sep 2013 04:25
URI: http://eprints.manipal.edu/id/eprint/137258

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