Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety

Chandrashekhar, Kumar B and Reddy, Venugopala KR and Fasiulla, . (2013) Synthesis, characterization and antimicrobial activity of some new 1,3,4-oxadiazoles and schiff bases bearing 5-chloroquinolin-8-ol moiety. Journal of Chemical and Pharmaceutical Research, 5 (8). pp. 154-161. ISSN 0975-7384

[img] PDF
JCPR-2013-5-8-154-161 CKB.pdf - Published Version
Restricted to Registered users only

Download (171kB) | Request a copy

Abstract

A new series of 2-(substituted phenyl)-5-(5-chloro quinolin-8-yloxy) methyl-1,3,4-oxadiazole (3a-j) were synthesised after refluxing 2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2) with different aromatic acids in presence of POCl3. A new series of N'-(substituted benzylidene)-2-(5-chloro-8-yloxy) acetohydrazide (schiff’ bases) (4a-j)were also synthesized from a mixture of2-[(5-chloro quinolin-8-yl) oxy] acetohydrazide (2)and different aromatic aldehydes in presence of glacial acetic acid. The chemical structures of these compounds were confirmed by various physic-chemical methods viz, IR, 1HNMR, mass spectral data and elemental analysis. Newly synthesized compounds were screen ed in vitro for their antimicrobial activity against varieties of gram +ve and gram -ve bacterial strains such as Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli and fungi strains Candida albicans & Aspergillus nigar with MIC at 40 μg/mL. The newly synthesized Schiff bases and 1,3,4- Oxadiazole derivatives bearing 5-chloroquinolin-8-ol are showing moderate to highly significant antimicrobial activity. The Schiff base (4i) shows highly significant antimicrobial activity as compare to other synthesized Schiff bases.

Item Type: Article
Uncontrolled Keywords: 5-chloroquinolin-8-ol, 1,3,4-Oxadiazoles, Schiff bases, antimicrobial activity
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 24 Sep 2013 05:00
Last Modified: 24 Sep 2013 05:00
URI: http://eprints.manipal.edu/id/eprint/137260

Actions (login required)

View Item View Item