Areca catechu: Effect of topical ethanolic extract on burn wound healing in albino rats

Verma, Deepak Kumar and Bharat, Masuram and Nayak, Deepak and Shanbhag, Tara and Shanbhag, Venkatesh and Rajput, Ravindra Singh (2012) Areca catechu: Effect of topical ethanolic extract on burn wound healing in albino rats. International Journal of Pharmacology and Clinical Sciences September, 1 (3). pp. 74-78.

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Background: Areca nut (Areca catechu Linn.) is commonly used for skin ulcers in Indian traditional medicine. Areca nut oil is prepared and is applied topically for burn wound healing. However, scientific study has not been conducted so far. Hence, this study was aimed to evaluate burn wound healing activity of Areca catechu. Objective: To evaluate the burn wound healing property of Areca catechu kernel in normal as well as dexamethasone treated rats. Materials and Methods: Ethanolic extract of Areca catechu kernel was prepared and an ointment was made with 2% of this extract. Burn wound was induced by standard procedure. Rats with burn wound model received either vehicle, standard drug or test drug. Two other groups were injected with dexamethasone to delay the wound healing process. The dexamethasone treated groups received either vehicle or test drug topically. Wound contraction rate and period of epithelialization were measured. The collected data were subjected to statistical analysis. Results: The wound contraction rate was significantly increased in Areca catechu treated group in all the days compared to control. Period of epithelialization was faster in the drug treated group than control group. The dexamethasone treated group showed a significant delay in wound healing process when compared to control. Test drug showed a significant reversal in wound contraction rate and epithelialization period in dexamethasone suppressed burn wound healing model. Conclusion: This study has shown the wound healing property of Areca catechu. Further study is required to know the compounds responsible for its wound healing property and to understand the mechanism of action.

Item Type: Article
Uncontrolled Keywords: Areca catechu, burn wound, epithelialization, wound contraction, Ayurveda, Siddha
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Surgery
Depositing User: KMCMLR User
Date Deposited: 14 Feb 2014 06:57
Last Modified: 14 Feb 2014 06:57

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