(E)-1-(2,3-dimethoxyphenyl)-N-(4-methylpyridin-2-yl)methanimineas a potent anticancer agent against colorectal cancer

Sunil, Dhanya and Ranjitha, . and Balaji, S and Pai, KSR (2014) (E)-1-(2,3-dimethoxyphenyl)-N-(4-methylpyridin-2-yl)methanimineas a potent anticancer agent against colorectal cancer. International Journal of Pharmaceutical Chemistry, 4 (1). pp. 11-14. ISSN 2249-734X

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Abstract

Colorectal cancer is the third common malignancy in man, with a significant morbidity and mortality rate. Three Schiff bases were synthesized by aminocondensation of 4-methyl-2-amino pyridine and three aromatic aldehydes and characterized by CHN analysis and advanced spectral techniques. They were screened for their cytotoxic properties using Sulphorhodamine-B (SRB) assay, and their antimigratory properties using wound healing assay against HCT116 (human colon cancer) cell lines. (E)-1-(2,3-dimethoxyphenyl)-N-(4-methylpyridin-2-yl)methanimine (DMPM) exhibited very low IC50 in SRB assay with good antimigratory activity as witnessed by wound healing assay. The protein processing enzyme MetAP2 has been identified as a molecular target for endothelial cell proliferation and angiogenesis and hence plays a key role in cancer therapy. The docking studies of DMPM with the active site of MetAP2 suggest it to be a potent chemotherapeutic agent in the treatment of colorectal cancer.

Item Type: Article
Uncontrolled Keywords: Schiff bases, cytotoxicity, migration, docking
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 26 Mar 2014 06:41
Last Modified: 26 Mar 2014 06:41
URI: http://eprints.manipal.edu/id/eprint/139212

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