Synthesis and biological evaluation of novel substituted 1, 3, 4-Thiadiazole and 2, 6-di aryl substituted imidazo [2, 1-b] [1, 3, 4]-thiadiazole derivative

Chandrakantha , B and Isloor, Arun M and Shetty, Prakash and Fun, Hoong-Kun and Hegde, Gurumurthy (2014) Synthesis and biological evaluation of novel substituted 1, 3, 4-Thiadiazole and 2, 6-di aryl substituted imidazo [2, 1-b] [1, 3, 4]-thiadiazole derivative. European Journal of Medicinal Chemistry, 71. pp. 316-323. ISSN 0223-5234

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Abstract

A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4 (a-l) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6 (a-l) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole -2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a, 4c and 6e, 6g displayed appreciable activity at the concentration 0.5-1.0 mg/mL

Item Type: Article
Uncontrolled Keywords: 1,3,4-Thiadiazole; 2,6-Diaryl imidazo [2,1-b] [1,3,4] thiadiazole; Antibacterial; Antifungal activity
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 07 May 2014 05:31
Last Modified: 07 May 2014 05:31
URI: http://eprints.manipal.edu/id/eprint/139449

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