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3-[(E)-(4-Hydroxy-3-methoxybenzylidene)amino]-2- thioxoimidazolidin-4-one as Snail1 Inhibitor with Anticancer and Anti-migratory Properties Against Colorectal Cancer

Sunil, Dhanya and Ranjitha, C and Murugappan, Rama and Balaji, S (2014) 3-[(E)-(4-Hydroxy-3-methoxybenzylidene)amino]-2- thioxoimidazolidin-4-one as Snail1 Inhibitor with Anticancer and Anti-migratory Properties Against Colorectal Cancer. Chemical Science Transactions, 3 (4). pp. 1562-1568. ISSN 2278-3318

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Abstract

Colorectal cancer is the third leading cause of cancer related deaths in humans. Research is going on to increase the treatment options of colon cancer with decreased side effects. Four imidazolidinones were synthesized by the cyclization reaction between Schiff bases and ethylchloroacetate and were characterized by advanced spectral techniques and CHN analysis. The cytotoxic and anti-migratory properties of imidazolidinones against HCT116 (human colorectal adenocarcinoma) cells were studied using Sulphorhodamine-B (SRB) assay and wound healing assay respectively. 3-[(E)-(4-Hydroxy-3-methoxybenzylidene)amino]-2-thioxoimidazolidin-4-one (2d) displayed excellent cytotoxicity with low IC50 in SRB assay. The wound gap observed on treatment with 2d indicated the reduced motility of HCT116 cells. Snail1, an E-Cadherin repressor plays an important role in epithelial to mesenchymal transition which influences metastatic cancer and hence, a molecular target in cancer treatment for anti-invasive drugs. The effective binding of 2d into the active site of snail1 in docking studies, suggests it to be a promising anti-neoplastic agent in the treatment of colorectal cancer.

Item Type: Article
Uncontrolled Keywords: Oxazepines, Cytotoxicity, Metastases, Snail1
Subjects: Engineering > MIT Manipal > Biotechnology
Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 10 Oct 2014 09:22
Last Modified: 15 Oct 2014 11:40
URI: http://eprints.manipal.edu/id/eprint/140821

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