Synthesis and in vitro Antimicrobial Evaluation of 5’-Acetamido-2'-Hydroxy Chalcone derivatives

Rao, Amita S and Simon, Lalitha and Srinivasan, KK and Moorkoth, Sudheer and Haleem, Zarah A and Jadon, Shivender S and Matsa, Ram M and Sagiraju, Ravivarma (2014) Synthesis and in vitro Antimicrobial Evaluation of 5’-Acetamido-2'-Hydroxy Chalcone derivatives. Research Journal of Chemical Sciences, 4 (2). pp. 1-4. ISSN 2231-606X

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Abstract

A series of chalcones (3a-j) were synthesized by Claisen-Schmidt condensation of aromatic aldehydes with 5’-acetamido-2’- hydroxyacetophenone. Paracetamol was acetylated using acetic anhydride and sulphuric acid. The acetylated paracetamol underwent Fries rearrangement to form 5’-acetamido-2’-hydroxy acetophenone. The antibacterial and antifungal activity of the test compounds were evaluated using the agar well diffusion method. The test compounds displayed activity against Candida albicans. The fluorinated chalcone 3c exhibited maximum inhibition. However the test compounds failed to show antibacterial activity.

Item Type: Article
Uncontrolled Keywords: Chalcone, antibacterial, antifungal, agar well diffusion method.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 10 Feb 2015 10:01
Last Modified: 10 Feb 2015 10:01
URI: http://eprints.manipal.edu/id/eprint/141852

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