Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety

Naveena, C S and Poojary, Boja and Arulmoli, Thangavelu and Manjunatha, Kumshi and Prabhu, A N and Kumari, Nalilu Sucheta (2012) Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety. Medicinal Chemistry Research , 22. pp. 1925-1937. ISSN 1554-8120

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Abstract

A series of 2,4-disubstituted-[1,3]-thiazoles (4a–p and 6a–l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a–d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data.All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a–p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea.

Item Type: Article
Uncontrolled Keywords: 2-(Aryloxymethyl)benzothioamides 2,4-Disubstituted thiazoles Antimicrobial activity Anti-inflammatory activity
Subjects: Engineering > MIT Manipal > Chemistry
Engineering > MIT Manipal > Physics
Depositing User: MIT Library
Date Deposited: 09 Apr 2015 09:55
Last Modified: 02 Jun 2015 10:05
URI: http://eprints.manipal.edu/id/eprint/142360

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